| Title | Over-The-Barrier Transition State Analogues Provide New Chemistries for Inhibitor Design: The Case of Purine Nucleoside Phosphorylase. BIOCHEMISTRY 42 6057-6066 2003 | | Site | TBSGC | | PDB Id | | Target Id | Rv3307 | | Related PDB Ids 1g2o 1i80 | | Molecular Characteristics | | Source | Mycobacterium tuberculosis h37rv | | Alias Ids | TPS27512,15610443, P0A538, 15610443, O53359, NP_217824.1 | Molecular Weight | 27569.88 Da. | | Residues | 268 | Isoelectric Point | 5.51 | | Sequence | madprpdpdelarraaqviadrtgigehdvavvlgsgwlpavaalgspttvlpqaelpgfvpptaagha gellsvpigahrvlvlagrihayeghdlryvvhpvraaraagaqimvltnaagglradlqvgqpvlisd hlnltarsplvggefvdltdaysprlrelarqsdpqlaegvyaglpgphyetpaeirmlqtlgadlvgm stvhetiaaraagaevlgvslvtnlaagitgeplshaevlaagaasatrmgalladviarf | | | BLAST FFAS | | Structure Determination | | Method | XRAY | Chains | 3 | | Resolution (Å) | 1.90 | Rfree | 0.213 | | Matthews' coefficent | 2.37 | Rfactor | 0.183 | | Waters | 432 | Solvent Content | 48.15 |
| Ligand Information | | Ligands | PO4 (PHOSPHATE) x 3;DIH (3-HYDROXY-4-HYDROXYMETHYL-1-(4-OXO-4,4A,5,7A-) x 3 | | Metals | | | |
