| Title | The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action. Mol.Pharmacol. 67 1874-1881 2005 | | Site | ISPC | | PDB Id | 1u65 | Target Id | W00566 | | Molecular Characteristics | | Source | Torpedo californica | | Alias Ids | P04058, | Molecular Weight | 65902.66 Da. | | Residues | 586 | Isoelectric Point | 5.72 | | Sequence | mnllvtsslgvllhlvvlcqaddhsellvntksgkvmgtrvpvlsshisaflgipfaeppvgnmrfrrpe pkkpwsgvwnastypnncqqyvdeqfpgfsgsemwnpnremsedclylniwvpsprpksttvmvwiygg gfysgsstldvyngkylayteevvlvslsyrvgafgflalhgsqeapgnvglldqrmalqwvhdniqff ggdpktvtifgesaggasvgmhilspgsrdlfrrailqsgspncpwasvsvaegrrravelgrnlncnl nsdeelihclrekkpqelidvewnvlpfdsifrfsfvpvidgeffptslesmlnsgnfkktqillgvnk degsffllygapgfskdseskisredfmsgvklsvphandlgldavtlqytdwmddnngiknrdglddi vgdhnvicplmhfvnkytkfgngtylyffnhrasnlvwpewmgvihgyeiefvfglplvkelnytaeee alsrrimhywatfaktgnpnephsqeskwplfttkeqkfidlntepmkvhqrlrvqmcvfwnqflpkll natacdgelsssgtssskgiifyvlfsilylif | | | BLAST FFAS ProFunc GPSS |
| Structure Determination | | Method | XRAY | Chains | 1 | | Resolution (Å) | 2.61 | Rfree | 0.237 | | Matthews' coefficent | 3.17 | Rfactor | 0.187 | | Waters | 241 | Solvent Content | 61.20 |
| Ligand Information | | Ligands | NDG-FUL (2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE) x 1;NAG (BETA-L-FUCOSE) x 2;NAG-FUC (N-ACETYL-D-GLUCOSAMINE) x 1;NAG-MAN (N-ACETYL-D-GLUCOSAMINE) x 1;CP0 (ALPHA-L-FUCOSE) x 1 | | Metals | IOD (IODIDE) x 1 | | |
