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1jq3

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Table of contents

1. Protein Summary
2. Ligand Summary

Molecular Characteristics
Title	The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor. Nat.Struct.Biol. 9 27-31 2002
Site	MCSG
PDB Id	1jq3	Target Id	APC047
Related PDB Ids 1inl
Source	Thermotoga maritima
Alias Ids	TPS4425,AAD35738, 2336	Molecular Weight	34140.37 Da.
Residues	296	Isoelectric Point	5.30
Sequence	mrtlkelerelqprqhlwyfeyytgnnvglfmkmnrviysgqsdiqridifenpdlgvvfaldgitmtt ekdefmyhemlahvpmflhpnpkkvliigggdggtlrevlkhdsvekailcevdglvieaarkylkqts cgfddpraeiviangaeyvrkfknefdviiidstdptagqgghlfteefyqacydalkedgvfsaeted pfydigwfklayrriskvfpitrvylgfmttypsgmwsytfaskgidpikdfdpekvrkfnkelkyyne evhvasfalpnfvkkelglm
	BLAST FFAS

Structure Determination
Method	XRAY	Chains	4
Resolution (Å)	1.80	Rfree	0.2290000
Matthews' coefficent	2.48	Rfactor	0.1960000
Waters	743	Solvent Content	50.42

Pathway
Reactions found in Metabolic Reconstruction for TM0654
Name: spermidine synthase Metabolic Subsystem: Spermidine Biosynthesis Reaction: : ametam Name:S-Adenosylmethioninamine Formula:C14H24N6O3S KEGG: C01137 + ptrc Name:Putrescine Formula:C4H14N2 KEGG: C00134 --> 5mta Name:5-Methylthioadenosine Formula:C11H15N5O3S KEGG: C00170 + h Name:H+ Formula:H KEGG: C00080 + spmd Name:Spermidine Formula:C7H22N3 KEGG: C00315 Classification: EC:2.5.1.16

Ligand Information
Ligands	AAT (S-ADENOSYL-1,8-DIAMINO-3-THIOOCTANE) x 3
Metals

1jq3

Resources
- PDB
- PDBSum
- PSI-KB
- PlasmID
- Proteopedia
- GPSS
- ProFunc

Protein Summary

Ligand Summary

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