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Protein Summary

This corresponds to the n-terminal FHA domain of the CEP170 protein, which is part of centrosome. The structure indicates that  CEP170-FHA lacks the canonical pThr recognition site, thus unlikely to involved in signaling by binding pThr containing peptide. Instead, it may play a role in protein-protein recognition.

The CEP-FHA domain forms a helical filament in the unit cell, but its biological relevance is not clear. We can not rule out that it could be an artifact of crystal packing, that may or may not have physiological relevance.

Fig. 1 the asu contains 5 mols that form into a helical filament, that extends throughout the space via symm ops

Ligand Summary