3t2l

Protein Summary

This structure is similar to previous JCSG structures 3gf8, 3liu, 3pay, 3r4r, 393142, likely involved in fimbrae formation. It demonstrate a novel form of oligomerization (dimer) through stand swapping.

This type of proteins are highly abundant in gut bacteria, potentially important for host interaction. Further investigation will be conducted when more structures become available (all targets will be tagged 3gf8-related).

This protein (BF1858) appears to be from the same operon as 393142(BF1861). It is noted that the putative operon consists of many proteins of similar fold.

bfs:BF1843           putative phage integrase/recombinase 
bfs:BF1844           hypothetical protein 
bfs:BF1845           putative integrase/transposase 
bfs:BF1846           hypothetical protein 
bfs:BF1847           hypothetical protein 
bfs:BF1848           hypothetical protein 
bfs:BF1849           hypothetical protein 
bfs:BF1850           hypothetical protein 
bfs:BF1851           ortholog to Mfa2, 3gf8 
bfs:BF1852           FimA family, major fibrae unit, ATP/GTP-binding chaperonin 
bfs:BF1853           hypothetical protein 
bfs:BF1854           paralog 
bfs:BF1855           paralog 
bfs:BF1856           paralog 
bfs:BF1857           paralog 
bfs:BF1858           paralog -solved 393159
bfs:BF1859           paralog 
bfs:BF1860           paralog 
bfs:BF1861           paralog -solved 393142
bfs:BF1862           hypothetical protein, paralog to BF1865, DUF1735, related to 3n91, 3nqk 
bfs:BF1863           paralog 
bfs:BF1864           paralog 
bfs:BF1865           hypothetical protein 
bfs:BF1866           paralog 
bfs:BF1867           hypothetical protein 
bfs:BF1868           contains a BACON domain, may bind carbohydrate or adhesion
bfs:BF1869           hypothetical protein 
bfs:BF1870           3ewl, hypothetical protein 

Fig. 1 domain swapped dimer

Ligand Summary