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The structure of protein DR_2006 (target ID 394616) from Deinococcus radiodurans, one of the most radioresistant organisms known, was determined by three wavelength Se-MAD at a resolution of 1.88 Angstroms. DR_2006 is a founding member of a new PFAM family DUF3809 (PF12723). Members of this family are found in extremophiles from the Deinococcus-Thermus phylum. This family is distantly related to other uncharacterized PFAM families, DUF1997 (PF09366) and DUF1885 (PF08968), possibly forming a new clan. The latter relation is confirmed by a significant structural similarity to a representative from the DUF1885 family solved by MCSG (1t6a).
Shown below is a ribbons representation of the structure color-coded with the N-terminal end in blue and the C-terminal end in red.
The structure of target ID 394616 shows a TBP-like fold, a fold found in the TATA box-binding proteins. The structure indicates that a dimer (see below) is a biologically-significant oligomerization state. Shown below is a ribbon representation of the the dimer with the individual chains in blue and yellow respectively.
A DALI search shows that the structure of target ID 394616 is similar to these other structures
| PDB ID | DALI Z-Score | rmsd overlap (Angstroms) | number of aligned residues | total residues in target | % sequence id | Description |
| 3ggn | 10.7 | 2.6 | 116 | 131 | 11 | DR_A0006 from Deinococcus radiodurans. Northeaset Structural Genomics Consortium Target DrR147D |
| 2d4r | 10.2 | 3.1 | 127 | 146 | 6 | TTHA0849 from Thermus thermophilus HB8 at 2.4 Angstrom resolution: a putative member of the StAR-related lipid-transfer (START domain superfamily. |
| 2ns9 | 9.7 | 3.6 | 127 | 152 | 9 | Protein APE2225 from Aeropyrim pernix,Pfam COXG |
| 2ejx | 9.6 | 2.9 | 120 | 134 | 5 | Hypothetical protein ST0812 fromSulfolobus tokodaii |
| 2rez | 8.7 | 3.3 | 119 | 155 | 6 | Tetracenomycin ARO/CYC NaI Structure |
| 2e3p | 8.3 | 3.1 | 131 | 231 | 4 | CERT START domain in complex with C16-cearmide (P1) |
| 2e3r | 8.3 | 3.1 | 131 | 226 | 4 | CERT START domain in complex with C18-ceramide (P1) |
| 2res | 8.3 | 3.4 | 120 | 152 | 5 | Tetracenomycin ARO/CYC mutant R69A |
| 1jss | 8.2 | 3.9 | 132 | 199 | 9 | Mus musculus cholesterol-regulated START protein 4 (StarD4). |
No references found.
| File | Size | Date | Attached by | |||
|---|---|---|---|---|---|---|
| dimer.png No description | 159.65 kB | 01:50, 22 Mar 2010 | haxelrod | Actions | ||
| monomer.png No description | 107.19 kB | 01:07, 22 Mar 2010 | haxelrod | Actions | ||
| mpd_density.png No description | 1077.05 kB | 22:40, 2 Jun 2010 | haxelrod | Actions | ||