3g3l

Protein Summary

YP_211325.1 is annotated as a hypothetical protein. The protein can not be assigned to any PFAM family either on the basis of its sequence.

The protein structure consists of beta-sheet mostly and two distinct domains can be seen in the structure: a small beta-barrel domain on the top and a larger strand+helix domain.

        Secondary structures                                                      N-terminal domain (green) and C-terminal domain (cyan)

The structure seems to be unique; a search for structural homologs through SSM and DALI servers does not return any significant hits.

Another search for structural homologs based on the two indidual domains of the protein return some hits.
N-terminal domain (residues 41-128):
DALI Results:

SSM Results:

C-terminal domain (residues 129-336):
DALI Results:

SSM     Results:

An examination of the above structures compared with this target indicates that 2boy (cyan) and 3e8v (magenta) are closest match to the N-terminal domain of this target (green) (see below). This suggests a possible role of transglutaminase/dioxygenase for the N-terminal domain.

 Although the top DALI hit, 1h8l, has the best match for 79 residues, this represents a small domain of this protein (see below) and thus may not represent the same function. Moreover, the Zn ion and the bound inhibitor, GEM, are located in the active site on the other side of the protein.

N-terminal domain (green) superimposed on 1h8l (magenta)

Similarly, the closest match for the C-terminal domain is 1w3f, a hemolytic lectin protein. A superposition is shown below (target green, 1wef magenta).  Judging by the differences in size of these structures as well as presence of helices in this target, it may not be reasonable to assign 1wef's function to this target.

Ligand Summary