3d8p

Protein Summary

Acetyltransferase of GNAT family, where Tyr129 (corresponds to Tyr141 in PDB:1tiq) is predicted as the catalytic residue. NP_373092.1 is from Staphylococcus aureus mu50.  Based on sequence alignment from NCBI blast and the predicted homologues Fold & Function Assignment System (FFAS and SSM), this target is structurally similar to 1TIQ, 1YR0, 2OB0, 2PSW and 2Q7B, which are acetyltransferase protein most likely.  Both SEC data and interaction interface calculation suggest the biomolecule of NP_373092.1 is a monomer.

    

    

Figure 1. Biomolecule of protein NP_373092.1 should be a monomer. 

    

Figure 2. Protein NP_373092.1(Green) is a structural homolog to those acetyltransferase, such as 1TIQ, 1YR0, 2OB0, 2PSW and 2Q7B.

Ligand Summary

Ca2+, Acetate ions

References

Forouhar, F.,  Lee, I.S.,  Vujcic, J.,  Vujcic, S.,  Shen, J.,  Vorobiev, S.M.,  Xiao, R.,  Acton, T.B.,  Montelione, G.T.,  Porter, C.W.,  Tong, L.  (2005) Structural and functional evidence for Bacillus subtilis PaiA as a novel N1-spermidine/spermine acetyltransferase.  J.Biol.Chem.  280: 40328-40336