3d1c

Protein Summary

NP_373108.1 is a likely  flavin-containing monooxygenase  (FMO), it is structurally similar to FMO from S. pombe (RMSD 2.36 for 264 aligned Ca, PDB code 2gvc/1vqw/2gv8). The solved structure contains a FAD. It also contains an unidentified ligand at the same place of methimazole in SmFMO. The active site residues,  though somewhat similar to SmFMO, are not completely conserved, suggesting possible differences in substrate specificity. O2*,O3*,O4* positions of FAD in this enzyme also differs from SmFMO.

NP_373108.1 functions as a monomer. It may also bind NADPH or NADH (NP_373108.1 contains a Pyridine nucleotide-disulphide oxidoreductase (PF07992: Pyr_redox_2) domain from Pfam, which according to Pfam is a small NADH binding domain within a larger FAD binding domain.