3cvj

Protein Summary

Gene BH3325 from Bacillus halodurans encodes the NP_244191 amino acid sequence that shows a weak hit (E-val=1.2e-3) with the Sugar Isomerase group (PF01380). A functional link (score 0.7) is made by genome context analysis with the glucose-1-phosphate thymidyl-transferase BH3324. 

Pre-SCOP classifies 3cvj in the alpha/beta class, SIS domain superfamily. 3cvj structure belongs to the alpha beta class having 3-layer (abc) sandwich architecture. There are four molecules in asu as shown below. The predicted biological molecule is a dimer supported by SEC/SLS. A Mg ion is coordinated by the side chains of His-53 and Glu-57 from both chains A and B. 

DALI top hits (Z=19) for a 3cvj structural similarity search are phosphoheptose isomerases PDB:3bjz, PDB:2i2w and the hypothetical protein HI0754 PDB:1nri. Superposition with the SSM best hit (PDB:1x92 - phosphoheptose isomerase; Z=18) with 3cvj is shown below.

Ligand Summary

Magnesium (Mg) and acetate (ACT) ions from crystallization and ethylene glycol (EDO)
from cryo condition were modeled.

References