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3cea

Table of contents
  1. 1. Protein Summary

Title Crystal structure of myo-inositol 2-dehydrogenase (NP_786804.1) from Lactobacillus plantarum at 2.40 A resolution.
Site JCSG
PDB Id 3cea Target Id 379488
Molecular Characteristics
Source Lactobacillus plantarum
Alias Ids NP_786804.1 Molecular Weight 38097.39 Da.
Residues 345 Isoelectric Point 5.15
Sequence mvttrkplraaiiglgrlgerharhlvnkiqgvklvaacaldsnqlewaknelgvettytnykdmidten idaifivaptpfhpemtiyamnaglnvfcekplgldfnevdemakvikshpnqifqsgfmrryddsyry akkivdngdigkiiymrgygidpisgmesftkfateadsggifvdmnihdidlirwftgqdpvqayglt sniaapqladigefetgvaqlkmsdgviatliggrhaahgnqvelevmgsngwvrigehpdlnrvtvfn dqgvvrpslqsfgerfdtaftdevqdfvnnvivgkqpevtvddgikalkiakacqqsanigklvdiql
  BLAST   FFAS

Structure Determination
Method XRAY Chains 4
Resolution (Å) 2.40 Rfree 0.243
Matthews' coefficent 2.23 Rfactor 0.193
Waters 345 Solvent Content 44.84

 

Ligand Information
Ligands NAD (NICOTINAMIDE-ADENINE-DINUCLEOTIDE) x 4;EDO (1,2-ETHANEDIOL) x 3
Metals CL (CHLORIDE) x 1
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Protein Summary

This protein, myo-inositol 2-dehydrogenase, belongs to the PFAM family of PF01408; GFO_IDH_MocA. The biomolecule is tetramer. Each monomer has a fold common to Oxidoreductase, but the tetramer orients such that two long sheets form a channel of some sort with helices on either side of the channel. The flanking domain adopts the oxidoreductase fold.

Fig.1 Tetramer showing one NAD bound to each monomer.

 
Fig. 2 Two orthogonal views showing a channel formed by beta sheets.

The monomer has a common fold with several homologs in the PDB (e.g. 2GLX 1OFG 1ZH8 2IXA 2NVW 2P2S 1YDW 1TLT 1GCU 2HO3 1XEA). Of these, 2GLX, 1OFG, 1ZH8 ,2IXA,  2P2S  also have NAD bound to them in identical location.

Ligand Summary

NAD is bound to the protein.

References

Reviews

References

 

No references found.

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channel_1.png
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224.26 kB22:05, 30 Jun 2008dweekesActions
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