The Open Protein Structure Annotation Network
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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of S-adenosylmethionine dependent methyltransferase (NP_104914.1) from Mesorhizobium loti at 1.60 A resolution. To be published
    Site JCSG
    PDB Id 3bkw Target Id 379544
    Molecular Characteristics
    Source Mesorhizobium loti maff303099
    Alias Ids TPS1744,NP_104914.1, 104890 Molecular Weight 27044.23 Da.
    Residues 242 Isoelectric Point 5.79
    Sequence maqniydqpdffagysqlgrsiegldgaaewpalramlpevgglrivdlgcgfgwfcrwahehgasyvl gldlsekmlararaagpdtgityeradldklhlpqdsfdlaysslalhyvedvarlfrtvhqalspggh fvfstehpiymaparpgwaidaegrrtwpidrylvegprktdwlakgvvkhhrtvgttlnalirsgfai ehveefcptdaqitarpelaeeldrpmfllvsarr
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 2
    Resolution (Å) 1.60 Rfree 0.200
    Matthews' coefficent 2.21 Rfactor 0.171
    Waters 487 Solvent Content 44.41

    Ligand Information



    Protein Summary

    The Mll3908 gene (PF08241 ,cd02440,cl12011) from Mesorhizobium loti MAFF303099 encodes for a methyltransferase (EC: which utilizes S-adenosylmethionine (SAM) as a donor for a methyl group to be added either at some nitrogen, oxygen or carbon atom. The structure adopts a Rossman fold (cf. SCOP, CATH). It is interesting to notice that this type of enzyme is also dependent on Mn2++ or Zn2++. Structurally similar proteins determined by the PSI include 3g5l (43% sequence identity over 203 structurally aligned residues, results obtained by TopMatch), 1vl5, 1xxl and many more since Rossman folds are very abundant.

    Todo: Possible improvement of this annotation: Do these Mn/Zn ions appear in the electron density?

    Ligand Summary





    No references found.

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