3bby
Table of contents
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Protein Summary
The yfcF from Escherichia coli k12encodes glutathione S-transferase (subfamily 4).This structure is structural and sequentially homologous to Glutathione S-transferase (GST, eg 6gss)
The A71 (glu) is important by structural alignment, also A71 is a clearly defined Ramachandran outlier. It is interesting to note that 40-57 is disordered, this seems to correlate with empty active site, it is likely that this segment is important for substrate binding.
PFAM entry http://pfam.sanger.ac.uk/family?acc=PF02798
Putative catalytic tyrosine is Tyr18. The additional analysis needs to be done to confirm Arg58 role in GSH binding.
Ligand Summary
References
Reviews
References
No references found.
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