Table of contents
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Protein Summary
The protein YP_265399.1 is annotated as putative valine--pyruvate aminotransferase. YP_265399.1 belongs to PFAM PF00155 Aminotran_1_2 which consists of aminotransferases. These proteins share certain mechanistic features with other pyridoxal-phosphate dependent enzymes, such as the covalent binding of the pyridoxal-phosphate group to a lysine residue. PLP is bound in both the chains in this structure,
The monomeric structure is shown below with the ligand PLP bound to it.
The protein forms a stable dimer as shown below.
There are several structurally similar proteins as found by a DALI search.
| N | PDB | Z-score | RMSD | LALI | NRES | %ID | TITLE |
|---|---|---|---|---|---|---|---|
| 1 | 3g7q | 52.1 | 1.5 | 383 | 388 | 46 | VALINE-PYRUVATE AMINOTRANSFERASE |
| 2 | 1gck | 39.8 | 2.5 | 372 | 382 | 22 | ASPARTATE AMINOTRANSFERASE |
| 3 | 1bkg | 39.7 | 2.5 | 372 | 382 | 22 | ASPARTATE AMINOTRANSFERASE |
| 4 | 1gc3 | 39.6 | 2.4 | 372 | 382 | 22 | ASPARTATE AMINOTRANSFERASE |
| 5 | 1x0m | 39.5 | 2.4 | 385 | 403 | 22 | AMINOTRANSFERASE II HOMOLOGUE |
| 6 | 1wst | 39.5 | 2.6 | 387 | 403 | 23 | MULTIPLE SUBSTRATE AMINOTRANSFERASE |
| 7 | 1gc4 | 39.5 | 2.4 | 371 | 382 | 21 | ASPARTATE AMINOTRANSFERASE |
| 8 | 5bj4 | 39.4 | 2.5 | 359 | 366 | 22 | PROTEIN (ASPARTATE AMINOTRANSFERASE) |
| 9 | 1b5p | 39.3 | 2.6 | 372 | 382 | 22 | PROTEIN (ASPARTATE AMINOTRANSFERASE) |
| 10 | 1bjw | 39.2 | 2.6 | 372 | 382 | 21 | ASPARTATE AMINOTRANSFERASE |
Some of these proteins have ligands bound in the same location as this protein. An overall superposition and a zoomed-in view of the active site are shown below.
YP_265399.1 (green), 1b5p (cyan), 1bjw (lightmagenta), 1bkg (yellow), 1gc3 (salmon), 1gc4 (lightgrey), 1gck (slate), 1wst (orange), 1x0m (lime), 3g7q (deepteal), 5bj4 (hotpink)
Literature references
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Nakai T, Okada K, Akutsu S, Miyahara I, Kawaguchi S, Kato R, Kuramitsu S, Hirotsu K; , Biochemistry 1999;38:2413-2424.: Structure of Thermus thermophilus HB8 aspartate aminotransferase and its complex with maleate. PUBMED:10029535
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Ko TP, Wu SP, Yang WZ, Tsai H, Yuan HS; , Acta Crystallogr D Biol Crystallogr 1999;55:1474-1477.: Crystallization and preliminary crystallographic analysis of the Escherichia coli tyrosine aminotransferase. PUBMED:10417420
Ligand Summary
Reviews
References
No references found.
Images (6)
