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2rhm
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Protein Summary
The Caur_3907 gene from Chloroflexus aurantiacus j-10-fl encodes the YP_001637473 sequence (obsolete entry ZP_00765535), a 192 residues long protein showing a weak hit with the zeta toxin group (PF06414). Its sequence profile is characterized by the conserved motif G11-//-G16-K17-T18. In the tetrameric crystal structure residues G16 and T18 of each monomer are chelating a Cl ion together with 2 ordered water molecules.
SCOP classifies 2rhm in the alpha/beta class, P-loop containing nucleoside triphosphate hydrolase superfamily, nucleoside/nucleotide kinase family. Reliable structural similarity (FFAS scr=-33; HHpred P-val=1e-28; Dali Z-scr=15; FATCAT P-val=1e-8) is observed with PDB:1qf9, a UMP/CMP kinase [Ref]; and with PDB:1rkb, a human adenylate kinase [Ref].
Ligand Summary
References
Reviews
References
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pH influences fluoride coordination number of the AlFx phosphoryl transfer transition state analog. Nat Struct Biol. 1999 Aug; 6(8):721-3 PubMed HubMed doi:10.1038/11485 pmid:10426946.
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The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus. Proc Natl Acad Sci U S A. 2005 Jan 11; 102(2):303-8 PubMed HubMed doi:10.1073/pnas.0407459102 pmid:15630091.
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