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T. maritima Browser
2rgq
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Protein Summary
The Npun_R3134 gene from Nostoc punctiforme pcc 73102 encodes the YP_001866547 protein of unknown function that adopts a cystatin-like fold. HHPred strongly predicts homology of Npun_R3134 with the ring hydroxylating beta subunit of nonheme iron-containing dioxygenases (PF00866, P-value 6.8E-18 over residues 17-130), the association domain of protein kinases (PF08332, P-value 3E-15 over residues 7-123), scytalone dehydratases (PF02982, P-value 1.8E-11 over residues 2-129) and other members of the NTF2 clan all of which adopt the same (cystatin-like) fold.
SCOP classifies 2rgq in the alpha+beta class, cystatin-like fold, NTF2-like superfamily, Rv3472-like family. DALI top hits are with the Rv3472 protein PDB:2chc (Z=19), the uncharacterized protein PDB:3b8l (Z=18), and the putative scyalone dehydratase PDB:3ef8 (Z=17).
To do: look for presence of active site residues, iron/aromatic compound binding site; compare oligomerization states in the different members of the clan.
Ligand Summary
References
Reviews
References
No references found.
