2qyc

Protein Summary

Gene BB1511 from Bordetella bronchiseptica encodes the NP_888056 protein that belongs to the Dabb family (Stress responsive A/B Barrel Domain) PF07876. This protein is also related to BB0372 (35% seq.id.) of unknown function.

2qyc has an alpha+beta structure that adopts a ferredoxin-like fold, inside the dimeric alpha+beta barrel superfamily, plant stress induced protein family of SCOP. According to a DALI search, 2qyc shows structural similarity to plant stress-induced proteins, namely the boiling stable protein (PDB:1tr0; Z=14, 19% sequence identity) from Populus tremula and proteins AT3G17210.1 (PDB:1q4r, PDB:1q53; Z=13-11) and AT5G22580 (PDB:1rjj; Z=11) from Arabidopsis thaliana. The smallest stable unit of all these beta-barrel plant proteins is a dimer, which is further packed in higher-order oligomers. Interestingly 2qyc crystallizes as a dimer but does not form higher-order oligomers. Furthermore, the dimer interface is not conserved when compared to the boiling stable protein 1tr0 [Ref] where residues Lys-10, Glu-68, Tyr-105 participate in an extensive hydrogen bonding and salt bridge network across different copies of the protein chains. 

Ligand Summary

References