2qww
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Protein Summary
The LMHCC_1836 gene (PF01047, cl00088) from Listeria monocytogenes 4b F2365 encodes for a multiple antibiotic resistance protein from the marR family. Even though the Pfam hit is rather weak, structure similarity to other MarR proteins like 3gfi [Ref] is confirming this annotation. These all-alpha proteins are short (135aa) transcriptional regulators and bind DNA via a winged helix/turn/helix motif (wHTH) as a dimer, with each monomer rbinding to half of a two fold symmetric DNA recognition sequence. Other MarR structures determined by PSI include 2a61, 3bj6, and 1lj9 [Ref].
Ligand Summary
References
Reviews
References
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ST1710-DNA complex crystal structure reveals the DNA binding mechanism of the MarR family of regulators. Nucleic Acids Res. 2009 Aug; 37(14):4723-35 PubMed HubMed doi:10.1093/nar/gkp496 pmid:19509310.
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Crystal structure of Enterococcus faecalis SlyA-like transcriptional factor. J Biol Chem. 2003 May 30; 278(22):20240-4 PubMed HubMed doi:10.1074/jbc.M300292200 pmid:12649270.
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