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2oik
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Protein Summary
The gene Mfla_2506 from Methylobacillus flagellatus encodes the YP_546612, a histidine triad protein (HIT) from the group PF01230.
2oik belongs to the class of alpha and beta (a+b) proteins and adopts a HIT-like fold SCOP54196, inside the HIT family of protein kinase interacting proteins. DALI top hits are with the HIT proteins like PDB:3i4s (Z=15), PDB:3lb5 (Z=13), PDB:1y23 (Z=12) and PDB:6fit (Z=12).
The HIT motif H-x-H-x-H-x (HVHWHV) is highly conserved among HIT homologues. On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases; the Fhit branch, that consists of diadenosine polyphosphate hydrolases; and the GalT branch consisting of specific nucloside monophosphate transferases. Fhit homologues are diadenosine polyphosphate hydrolases and function as tumour suppressors in human and mouse. GalT homologues transfer nucleoside monophosphate moieties to phosphorylated second substrates rather than hydrolysing them.
Ligand Summary
References
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References
No references found.
