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T. maritima Browser
2hh6
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Protein Summary
The gene BH3980 from Bacillus halodurans probably encodes the NP_244848 protein, a transcriptional regulator from the DUF1048 group (PF06304), homologous to PadR 3HHH (sequence identity with YP_003354695 is 44%) and LmrR 3F8B families of transcription regulators.
SCOP classifies 2hh6 inside the left-handed superhelix fold, BH3980-like (super)family. DALI only provides weak hits (Z=10) with the BH3976 protein 2o4t and 2o3l. The structure comparison searches using 2hh6 as query demonstrates significant similarities to these transcription regulators, although several structural features differ. PadR acts as a repressor of padA gene expression in the phenolic acid stress response, which is important in plant-soil ecosystems. LmrR is PadR-related transcriptional repressor that regulates the production of LmrCD, a major multidrug ABC transporter in Lactococcus lactis. Transcriptional regulation is presumed to follow a drug-sensitive induction mechanism involving the direct binding of transporter ligands to LmrR.
Ligand Summary
References
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References
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