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The Open Protein Structure Annotation Network
PDB Keyword
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2eth

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of Transcriptional regulator, putative, MAR family (tm0816) from Thermotoga maritima at 2.50 A resolution. To be published
    Site JCSG
    PDB Id 2eth Target Id 282686
    Molecular Characteristics
    Source Thermotoga maritima msb8
    Alias Ids TPS1237,TM0816, 85023 Molecular Weight 16386.06 Da.
    Residues 142 Isoelectric Point 5.22
    Sequence mdaleifktlfslvmrfssylpsneeisdmkttelyaflyvalfgpkkmkeiaeflsttksnvtnvvds lekrglvvremdpvdrrtyrvvltekgkeifgeilsnfesllksvlekfseedfkvvsegfnrmveals regr
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 2
    Resolution (Å) 2.30 Rfree 0.264
    Matthews' coefficent 2.65 Rfactor 0.227
    Waters 47 Solvent Content 53.27

    Ligand Information
    Ligands
    Metals

    Jmol

     
    Google Scholar output for 2eth
    1. Protein structural classification and family identification by multifractal analysis and wavelet spectrum
    SM Zhu, ZG Yu, A Vo - Chinese Physics B, 2011 - iopscience.iop.org
     
    2. Rapid Assay Development and Refinement for Targeted Protein Quantitation Using an Intelligent SRM (iSRM) Workflow
    R Kiyonami, A Schoen, A Prakash, H Nguyen - 2009 - thermoinformatics.com
     
    3. PHARMACOPROTEOMIC ANALYSIS OF THREE DIFFERENT CHONDROITIN SULFATE COMPOUNDS IN HUMAN CHONDROCYTES CULTURES
    I SITES - IEEE/ACM Trans Comput Biol Bioinform, 2011 - eupa.org
     
    4. P1 Endemic mycoses
    C Nationale, L Chemicals - 2012 - Wiley Online Library
     

    Protein Summary

    TM0816 gene from Thermotoga maritima encodes the NP_228625 protein, a putative transcriptional regulator from the MarR family (Pfam01047). TM0816 is involved in heat-shock response ([Ref]), where induction of this marR homolog plus several other putative transcriptional regulators (TM1023, TM1069), and two alpha-glucosidases (TM0434 and TM1068), indicate late heat-shock responses.

    The 2eth structure belongs to the SCOP all alpha class, winged-helix DNA binding domain superfamily, MarR-like transcriptional regulator family. A DALI search returns hits with the transcriptional regulator 1nyx (Z=13), the YUSO protein 1s3j (Z=13), the putativre MarR factor 2rdp (Z=13), and TM0710 2a61 (Z=13).



     

    Ligand Summary



    References

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