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Protein Summary
The gene TM1561 from Thermotoga maritima encodes an enzyme queuine tRNA-ribosyltransferase PF01702 COG1549 EC:2.4.2.29. Some other common names of this enzyme are tRNA-guanine transferase, tRNA guanine transglycosylase, guanine-tRNA transglycosylase, queuine-tRNA transglycosylase, q-insertase. Queuine is a hypermodified base that occurs in the wobble position of the anticodon of tRNAs of Asp, Asn, His and Tyr . Queuine tRNA-ribosyltransferase catalyzes the incorporation of queuine into tRNA via a base exchange reaction with guanine. In eukaryotes, queuine is directly exchanged into tRNA while in eubacteria, a queuine precursor (preQ1) is incorporated and ultimately modified to queuine [Ref]. The enzyme contains a zinc-binding motif. To date, structures of the enzyme homologues from multiple organisms have been solved (e.g. 1EFZ, Zymomonas mobilis; 1IT8, Pyrococcus horikoshii).
Ligand Summary
References
Reviews
References
