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T. maritima Browser
1vjx
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Protein Summary
The gene TM1526 from Thermotoga maritima encodes the NP_229326 protein, that belongs to the rubrerythrin group (PF02915) and folds into a ferritin-like AB domain found in Archaea and Bacteria COG1528. Genome context analysis provides a weak hit (score 0.57) with TM1526 neighbors, the endoglucanases celA (TM1524) and celB (TM1525).
SCOP classifies 1vjx inside the all alpha class, ferritin-like (super)family. A Dali structural similarity search with 1vjx as query yields as top hits: 2fzf (Z-scr=17) and the bacterioferritin 1nfv (Z-scr=16).
The protein is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. These proteins were sequenced from mostly anaerobic or microaerophilic metal-metabolizing and/or nitrogen-fixing microbes. The proteins containing this domain have broad functions. A subfamily of these proteins is known as DPS (DNA Protecting protein under Starved conditions) proteins. Some DPS proteins nonspecifically bind DNA, protecting it from cleavage caused by reactive oxygen species such as the hydroxyl radicals produced during oxidation of Fe(II) by hydrogen peroxide.
Ligand Summary
References
Reviews
References
No references found.
