1t6r

Protein Summary

The gene TM1442 from Thermotoga maritima encodes the NP_229241 protein, an anti-sigma factor antagonist domain of anti-anti-sigma factors (the STAS domain) PF01740 COG1366.  

SCOP classifies 1t6r in the alpha/beta class, SpoIIAA-like superfamily, anti-sigma factor antagonist family. 1t6r entry corresponds to the solution structure of TM1441 in the phosphorylated state [Ref]. Its crystal structure is available as PDB:1vc1. Significant DALI hits are found with anti-sigma F factor proteins PDB:1thn, PDB:1til, PDB:1tid (Z=16), and the TM1081 proteins PDB:3f43 and PDB:2ka5 (Z=15).

Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response) [Ref]. The STAS domain is also found in the C-terminal region of sulphate transporters and stressosomes.

Ligand Summary

References