1sj5

Protein Summary

The gene TM0160 from Thermotoga maritima encodes the NP_227975 protein of unknown function DUF151 PF02577. Analysis of TM0160 genome vicinity finds a possible functional partner based on shared neigborhood (score 0.87) with a geranyltrans-transferase (TM0161).

SCOP classifies 1sj5 in the alpha+beta class, TM0160 fold and family. DALI finds no significant hits (Z<3).

A BLAST sequence alignment includes the C-terminal domain of the UvrB/UvrC protein from Polaribacter sp. 2FDC with an E-value=3e-38, 31% amino acid sequence identity  and 7% gaps.  UvrB is the central component in the prokaryotic nucleotide excision repair system.

Additionally, DUF151 can be related structurally to the family of response regulators REC, like CheY protein ( 3F7N).  The response regulators act as phosphorylation-activated switches that affect a cellular response, usually by transcriptional regulation. Most of these proteins consist of two domains, an N-terminal response regulator receiver domain, and a variable C-terminal effector domain with DNA-binding activity.  Thus, temptatively DUF151 could be a C-terminal effector domain with DNA-binding activity of either DNA repair enzyme or a REC-like protein.

1SJ5 is the N-terminal fragment of 1VJL structure.

Ligand Summary

References