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T. maritima Browser
1rdu
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Protein Summary
The gene TM1290 from Thermotoga maritima encodes protein belonging to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme (dinitrogenase iron-molybdenum cofactor PF02579). This domain is a predicted small-molecule-binding domain (SMBD) with an alpha/beta fold that is present either as a stand-alone domain (e.g. NifX and NifY) or fused to another conserved domain (e.g. NifB). NifB appears to be an iron-sulphur source for FeMo-co biosynthesis, while NifX may be associated with the mature FeMo-co, in particular with the addition of homocitrate during the last step of biosynthesis [Ref]. This conserved domain is represented in two of the three major divisions of life (bacteria and archaea).
This is one of several proteins from this family ( 1o13 (T. maritima ortholog TM1816), 2re2, 2kla) solved by JCSG.
Ligand Summary
References
Reviews
References
