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The TM1171 gene from T. maritima encodes the NP_228976 protein, a transcriptional regulator (CrP family) that belongs to PF00027 (cyclic nucleotide binding domain) and to COG0664 (cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases).
1o5l has significant structural similarity to other transcriptional regulators from Crp/Fnr family (PDB structure 2gau ; DALI Z-score 15.0; RMSD 2.9; 25% sequence identity within 122 superimposed residues) and also to other PDB structures (1pf0, 2beo, 1o7f, 1zyb, 2h6b) with double-stranded beta-helix SCOP fold [51181].
Analysis of the crystallographic packing of 1o5l using the PQS server {Henrick, 1998 #73} indicates that a dimer is the biologically relevant form.
No references found.