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1o50
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Protein Summary
Gene TM0935 from Thermotoga maritima translates in the NP_228743 protein that folds into a tandem cystathionine-beta-synthase (CBS) domain (PF00571; COG0517). CBS domains are widely distributed in all divisions of life, in the form of fusions with various unrelated proteins, where they usually form tandem pairs of about 120 aa that folds into one domain with a beta-sandwich and 4 alpha-helices extending from one edge [Ref]. Analysis of the genome context of TM0935 indicates the possible functional linkage (score 0.87) with the 5-methylthioadenosine deaminase mtaD (TM0936).
1o50 classifies inside the alpha+beta class, CBS-domain pair (super)family. DALI top hits are with CBS domain protein PDB:2rc3 (Z=16), the MJ0100 protein PDB:3kpc (Z=16), and the YQZB protein PDB:3fv6 (Z=16).
Functions of CBS domains are related to its ability to bind adenosyl-containing molecules to serve as energy or redox status sensing modules (PubMed: [Ref], [Ref], [Ref]). Cystathionine beta-synthase (CBS-domain containing protein) may function in oxidative stress defense by trans-sulfuration pathway [Ref], where S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity [Ref].
Ligand Summary
References
Reviews
References
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Natural history of S-adenosylmethionine-binding proteins. BMC Struct Biol. 2005 Oct 14; 5:19 PubMed HubMed doi:10.1186/1472-6807-5-19 pmid:16225687.
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CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. J Clin Invest. 2004 Jan; 113(2):274-84 PubMed HubMed doi:10.1172/JCI19874 pmid:14722619.
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Bateman domains and adenosine derivatives form a binding contract. J Clin Invest. 2004 Jan; 113(2):182-4 PubMed HubMed doi:10.1172/JCI20846 pmid:14722609.
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Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein. Arch Biochem Biophys. 2005 Jan 1; 433(1):144-56 PubMed HubMed doi:10.1016/j.abb.2004.08.037 pmid:15581573.
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The distribution of cystathionine beta-synthase (CBS) in the eye: implication of the presence of a trans-sulfuration pathway for oxidative stress defense. Exp Eye Res. 2006 Oct; 83(4):817-23 PubMed HubMed doi:10.1016/j.exer.2006.04.001 pmid:16769053.
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S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. Proc Natl Acad Sci U S A. 2006 Apr 25; 103(17):6489-94 PubMed HubMed doi:10.1073/pnas.0509531103 pmid:16614071.
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