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1o4w

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 A resolution. Proteins 56 404-408 2004
    Site JCSG
    PDB Id 1o4w Target Id 354418
    Molecular Characteristics
    Source Archaeoglobus fulgidus dsm 4304
    Alias Ids TPS1330,2650039 Molecular Weight 15466.17 Da.
    Residues 135 Isoelectric Point 8.50
    Sequence meadrgrnnkvrcavvdtnvlmyvylnkadvvgqlrefgfsrflitasvkreleklemslrgkekvaar falkllehfevvetesegdpslieaaekygcilitndkelkrkakqrgipvgylkedkrvfvelld
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 1
    Resolution (Å) 1.90 Rfree 0.23508
    Matthews' coefficent 3.04 Rfactor 0.18843
    Waters 90 Solvent Content 59.23

    Ligand Information
    Ligands
    Metals

    Jmol

     
    Google Scholar output for 1o4w
    1. Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex
    F Glavan, I Behm-Ansmant, E Izaurralde, E Conti - The EMBO journal, 2006 - nature.com
     
    2. AbrB-like transcription factors assume a swapped hairpin fold that is evolutionarily related to double-psi _ barrels
    M Coles, S Djuranovic, J Sding, T Frickey, K Koretke - Structure, 2005 - Elsevier
     
    3. Structural characterization of proteins using residue environments
    SD Mooney, MHP Liang, R DeConde - PROTEINS: Structure, , 2005 - Wiley Online Library
     
    4. Crystal structure of PAE0151 from Pyrobaculum aerophilum, a PIN_domain (VapC) protein from a toxin_antitoxin operon
    RD Bunker, JL McKenzie, EN Baker - Proteins: Structure, , 2008 - Wiley Online Library
     
    5. Interleukin_1_inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL_1_ mRNA
    D Mizgalska, P W_grzyn, K Murzyn, A Kasza - FEBS , 2009 - Wiley Online Library
     
    6. Crystal structure of a PIN (PilT N_terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 resolution
    I Levin, R Schwarzenbacher, R Page - Proteins: Structure, , 2004 - Wiley Online Library
     
    7. 3DSwap: curated knowledgebase of proteins involved in 3D domain swapping
    K Shameer, PN Shingate, SCP Manjunath - , 2011 - database.oxfordjournals.org
     
    8. Structural and functional analysis of the archaeal endonuclease Nob1
    T Veith, R Martin, JP Wurm, BL Weis - Nucleic Acids , 2011 - Oxford Univ Press
     

    Protein Summary

    The AF0591 gene from Archaeoglobus fulgidus encodes the NP_069425 protein from the PilT N-term./Vapc superfamily (COG1412). It belongs to the PIN group (PF01850).

    Genomic neighbourhood and phylogenetic cooccurrence (STRING) indicates that AF0591 functions are related to protein translation. PilT-N terminal domain probably cleaves ribosome-associated transcripts (http://genomebiology.com/2003/4/12/R81).

      1o4w has a PIN domain-like fold (SCOP sunid: 88722) with 3 layers (?/?/?) core: parallel ?-sheet of 5 strands, order 32145, and is similar to: 2fe1A, 1w8iA, 1v8oA, 1y82A, 1v96A.

    Ligand Summary



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