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1o4u
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Protein Summary
The TM1645 gene from Thermotoga maritima encodes the NP_229445 protein, a type II quinolic acid phosphoribosyltransferase (QAPRTase, NadC, EC:2.4.2.19, PubMed:15103640), which is an essential enzyme in the NAD+ biosynthetic pathway. This enzyme catalyzes the transfer of a phosphoribosyl moiety from 5-phosphoribosyl-1-pyrophosphate (PRPP) to quinolinic acid (QA), yielding nicotinic acid mononucleotide (NAMN), pyrophosphate and CO2, the last resulting from decarboxylation at position 2 of the quinolinate ring.
The active enzyme exists as a dimer, where each monomer has two domains with different fold. The N-terminal domain (PF02749) has alpha/beta-Hammerhead fold (SCOP sunid:54664) and belongs to the family of quinolinic acid phosphoribosyltransferase N-terminal domain (SCOP sunid: 54676). The C-terminal domain (PF01729) has a TIM beta/alpha-barrel fold (SCOP sunid:51350) and belongs to a superfamily with characteristic incomplete beta/alpha barrel with parallel beta-sheet of 7 strands (Quinolinic acid phosphoribosyltransferase C-terminal domain; SCOP sunid:51690). DALI top hits are with other pyrophosphorylases like PDB:2jbm (Z=30), PDB:2b7n (Z=28), PDB:3l0g (Z=28), PDB:1x1o (Z=28).
Ligand Summary
References
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References
No references found.
