| Title | Crystal structure of N-acetylglucosamine-6-phosphate deacetylase (TM0814) from Thermotoga maritima at 2.5 A resolution. To be published | | Site | JCSG | | PDB Id | | Target Id | 282684 | | Molecular Characteristics | | Source | Thermotoga maritima msb8 | | Alias Ids | TPS1236,TM0814 | Molecular Weight | 40200.31 Da. | | Residues | 364 | Isoelectric Point | 5.59 | | Sequence | mivekvlivdpidgeftgdveieegkivkvekreciprgvlmpgfvdphihgvvgadtmncdfsemeef lysqgvttflattvstslekmkeilrkardyilenpstsllgvhlegpyiskekkgahsekhirppser elseidspakmltfapeiesselllrlvkrdivlsaghsiatfeefmkfykegvkrithfpnglkplhh reigitgaglllddvklelicdgvhlsremvklvykvkkangivlvtdsisaaglkdgtttlgdlvvkv kdgvprledgtlagstlffsqavknfrkftgcsitelakvssynscvelglddrgriaegtradlvlld edlnvvmtikegevvfrsr | | | BLAST FFAS | | Structure Determination | | Method | XRAY | Chains | 2 | | Resolution (Å) | 2.50 | Rfree | 0.251 | | Matthews' coefficent | 2.64 | Rfactor | 0.195 | | Waters | 206 | Solvent Content | 52.99 |
| Pathway | | Reactions found in Metabolic Reconstruction for TM0814 | Name: N-acetylglucosamine-6-phosphate deacetylase (reversible)
Metabolic Subsystem: Aminosugar Metabolism
Reaction: :
acgam6p
Name:N-Acetyl-D-glucosamine 6-phosphate
Formula:C8H14NO9P
KEGG:
C00357
+
h2o
Name:H2O
Formula:H2O
KEGG:
C00001
<==>
ac
Name:Acetate
Formula:C2H3O2
KEGG:
C00033
+
gam6p
Name:D-Glucosamine 6-phosphate
Formula:C6H13NO8P
KEGG:
C00352
Classification: EC:3.5.1.25
|
| Ligand Information | | Ligands | | | Metals | | | |
Protein Summary
The TM0814 gene from Thermotoga maritima encodes N-acetylglucosamine-6-phosphate deacetylase, a member of aminohydrolase family, a subset of metal-dependent hydrolases superfamily PF01979 COG1834. The enzyme includes the catalytic domain of urease alpha subunit homologous to that from Klebsiella aerogenes [Ref].
Ligand Summary
References
