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Protein Summary

The gene TM1102 from Thermotoga maritima encodes ribonuclease III enzyme EC:3.1.26.3.  The enzyme has two domains belonging to distinct superfamilies.  The N-terminal domain encodes ribonuclease III domain PF00636, while the C-terminal domain contains the double-stranded RNA binding motif (DsRBD) PF00035. The ribonuclease III catalyzes the digestion of double-stranded RNA. It is involved in the processing of ribosomal RNA precursors and of some mRNAs [Ref].  The DsRBD domain is found in a variety of RNA-binding proteins with different structures and exhibiting a diversity of functions [Ref]. It is involved in localisation of at least five different mRNAs in the early Drosophila embryo and by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA.

Ligand Summary

References