1j6p

Protein Summary

TM0936 has a fold typical for a amidohydrolase superfamily (AHS), consisting of two domains, a TIM barrel and a beta roll.

TM0936 is a S-adenosylhomocysteine (SAH) deaminase, part of a novel and as yet uncharacterized pathway of SAH degradation, as  recently demonstrated in Hermann JC, Marti-Arbona R, Fedorov AA, Fedorov E, Almo SC, Shoichet BK, Raushel FM.   "Structure-based activity prediction for an enzyme of unknown function." Nature. 2007 448:775-9

Ligand Summary

The JCSG structure was solved without a ligand. Subsequently, a complex of TM0936 with methionine (1p1m) was solved by the New York Structural GenomiX Research Consortium (NYSGXRC) and a complex with the product resulting from the deamination of SAH, S-inosylhomocysteine was solved by the Frank M. Raushel group at Texas A&M (2plm).