PF04672
Table of contents
- 1. Topsan Members
- 2. Summary
| Pfam Family | |
|---|---|
| Name: Methyltransf_19 | Accession: PF04672 (PFAM live) |
| Description | |
| S-adenosyl methyltransferase | |
| Comments | |
| This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure PDB:3giw from Swiss:Q82L35 suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22 . The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN). | |
Topsan Members
Tag pages as 'PF04672' to appear in this list.
| Name | Annotation | Author(s) |
2qe6
| The Tfu_2867 gene (PF04672, also known as DUF574) from Thermobifida fusca YX encodes the YP_290923 protein of unknown function. 2qe6 adopts a Rossman fold (2qe6-CATH). Pre-SCOP puts 2qe6 in the alpha... | chrisx (3 edits) pascual (2 edits) |
Summary
Pfam family PFAM:PF04672 {Protein of unknown function (DUF574)} with 142 members in NR database and additional 1 members in the metagenomic datasets is represented in Bacteria. The first structural representative solved (PDB Id: TOPSAN:2qe6) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d1rjda_ classified as S-adenosyl-L-methionine-dependent methyltransferase fold. Profile-profile methods confirm remote homology between this family and superfamily of S-adenosyl-L-methionine-dependent methyltransferases; fold of the same name. Based on remote homology confirmed by the structure, ligand one can hypothesize that this family is probably involved in transfer of methyl groupReviews
References
No references found.
You must login to post a comment.