JCSG Structures of RRM domains

Summary

Classical RNA Recognition Motifs (RRMs) are one of the most abundant RNA binding domains, being present in over 400 copies in over 200 proteins in the human proteome alone. More divergent RRM domains are also found and their numbers are more difficult to estimate. RRM domains are present in proteins with different domain architectures, including many cases of apparent internal duplications. RRM domains have been extensively studied, being involved in splicing, cell differentiation control and other critical cell processes however not much is known about their evolution as a group. Here we analyze the evolution of the repertoire of RRM domains in eukaryotic genomes. We show that the last eukaryotic common ancestor (LECA) already had an extensive set of proteins with RRM domains representing a majority of architectures of such proteins seen in the today’s complex eukaryotes. This set expanded further by multiple independent rearrangements and duplications. One of the most common architecture of an RRM protein consists of a tandem RRM domain repeat (possibly accompanied by other domains, including other RRM domains). This architecture emerged independently several times during the eukaryotic evolution, including at least one example specific to primates.

Tag pages as 'jcsgRRMstructure' to appear in this list.

Name	Annotation	Author(s)
3ue2	The structure of a divergent, C-terminal RNA binding domain from a poly-U binding splicing factor 60KDa (PUF60) protein. JCSG made two depositions with different resolutions (3ue2 - 1.23 Å and 3us5 - ...	adam (3 edits)
3s7r	N-terminal (residues 60-145)  RRM domain of the Hhuman heterogeneous nuclear ribonucleoprotein A/B (...	adam (1 edits)
3tyt	This construct corresponds to the C-terminal half, residues 345-555, of Heterogeneous nuclear ribonucleoprotein L (HNRNPL). This entry covers two depositions - 3tyt and 3s01. The N-terminal domain be...	adam (2 edits)
3uwt	The structure of the first two RRM domains (residues 101-299 from the human poly-U binding splicing factor (60KDa, PUF60). These are "classical" RRM domains, covered by the PFAM RRM_1 family Pfam PF...	adam (1 edits)
3ucg	The RNA binding domain of human POLYADENYLATE-BINDING PROTEIN, PABP-2 or PABII. A classical RRM do...	adam (2 edits)
3ulh	N-terminal RRM domain from the THO complex 4 protein (THO4). A classical" RRM domains, covered by th...	adam (1 edits)
2lxi
3s6e	The C-terminal  RRM domain, for mouse RBM39 (RNA binding motif protein 39, UniProt Q8VH51), represen...	adam (1 edits)
3v4m	The structure of the C-terminal RRM domain of splicing factor U2AF U2AF , an essential splicing factor that recognizes the 3' splice site and recruits the U2 snRNP to the branch point. A classical RRM...	adam (1 edits)
2lmi	NMR structure of a central (140-217) RRM domain from human G-rich sequence factor 1 isoform 1 (GRSF1...	adam (1 edits)